Synthetic Route of 139152-08-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139152-08-2 as follows.
The mixture of 1-(2-hydroxyethyl)-4-(4-methoxybenzylamino)-3-p-tolyl-1H-1,2,4-triazol-5(4H)-one (1)(1.00 g, 2.82 mmol) and 4,5-dichlorophthalonitrile (2) (0.28 g, 1.41 mmol) were dissolved in dry DMF(15 mL) under a nitrogen atmosphere and this mixture was stirred at 50 C for 10 min. After stirring,finely ground anhydrous K2CO3 (0.58 g, 4.23 mmol) was added portionwise over a period of 2 h and thereaction mixture was stirred under nitrogen at this temperature for 5 days. At the end of this time, themixture was poured into ice water (100 mL) and stirred for 30 min. The reaction mixture was extractedwith chloroform (50 mL × 3) and the organic layer was dried over anhydrous magnesium sulfate andthen solvent was removed under reduced pressure. The oily green product was dried in vacuo (P2O5).Yield: 1.00 g (85%). Calcd for C46H44N10O6: % C 66.33, % H 5.32, % N 16.82. Found: % C 66.28, % H 5.30, %N 16.85. FT-IR numax cm-1 (NaCl disk): 3259 (N-H), 3033 (Ar-H), 2935-2837 (Aliph. C-H), 2233 (C?N), and1699 (C=O), 1613, 1513, 1422, 1250, 1176, 1035, 822 and 739. 1H NMR (CDCl3) (delta: ppm): 7.79 (ArH, 4H,d), 7.28 (ArH, 4H, d), 7.18 (ArH, 4H, d), 6.79 (ArH, 4H, d), 6.75 (ArH, 2H, d), 4.93 (NH, 2H, s), 4.43 (O-CH2,4H, t), 4.11 (CH2, 8H, m), 3.78 (O-CH3, 6H, s), 2.42 (CH3, 6H, s). 13C NMR (CDCl3) (delta: ppm): 159.63, 158.24,153.75, 153.41, 144.95, 140.95, 140.80, 135.15, 130.90, 129.32, 127.46, 123.41, 117.09, 115.84, 114.08,107.89, 67.12, 61.57, 55.49, 54.48, 49.39, 44.48, and 21.77. MS (ES+), m/z: Calcd: 832.92; Found: 832.37 [M]+.
According to the analysis of related databases, 139152-08-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Nas, Asiye; Journal of Coordination Chemistry; vol. 69; 8; (2016); p. 1326 – 1336;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts