Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6283-71-2, name is Dimethyl 2-cyanosuccinate, A new synthetic method of this compound is introduced below., Product Details of 6283-71-2
To a solution of dimethyl 2-cyanobutanedioate (compound 62a, 513 mg, 3 mmol) in acetone (5 mL) was added iodomethane (639 mg, 4.5 mmol) and potassium carbonate (829 mg, 6 mmol). The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was extracted with EtOAc twice, washed with water. The combined organic phase was dried over Na2SO4, filtrated and concentrated to give compound 62b (556 mg, crude). LCMS (M+H+): 186.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HU, Taishan; KOU, Buyu; LIN, Xianfeng; LIU, Haixia; ZHANG, Zhisen; (152 pag.)WO2018/11160; (2018); A1;,
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