In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1897-52-5 as follows. HPLC of Formula: C7H3F2N
20.0 g of 2,6-difluorobenzonitrile, anhydrous potassium carbonate 20.0 g and dimethyl sulfoxide 100 mL, add to the reaction flask, stir evenly, and warm to 90 C. Slowly drip morpholine 6.60g with stirring. Keep the temperature at 90 C for 3 hours. The reaction solution was naturally cooled to room temperature and poured into an appropriate amount of ice water. Precipitating a white solid powder, filtering, the filter cake was washed with water and dried to obtain 9.0 g of a product. That is, 2-fluoro-6-morpholinylbenzonitrile (1).
According to the analysis of related databases, 1897-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanxi University Of Science And Technology; Lu Jiufu; Jin Lingxia; Yu Xiaohu; Zhao Caibin; Zhou Ke; Song Juan; (7 pag.)CN109879827; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts