Adding a certain compound to certain chemical reactions, such as: 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34662-24-3, Quality Control of 2-Chloro-3-nitrobenzonitrile
A solution of anhydrous EtOH (20 mL) was bubbled through NH3 at 0C to obtain 7M NH3/EtOH. It was transfered intoa sealed tube containing 2-chloro-3-nitrobenzonitrile (0.5 g, 2.7 mmol, 1.0 eq). The mixture was allowed to warm to 18C gradually and then stirred at 110C for 12 hours. The mixture was evaporated under reduced pressure to remove the most solvent to give 0.5 g of crude 2- amino-3-nitrobenzonitrile as a yellow solid which was used in the next step without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts