Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19472-74-3, name is 2-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6BrN
2-Bromophenylacetonitrile (20.0 g, 0.1 mol) was dissolved in THF (100 mL), iced water,1 M borane tetrahydrofuran solution (200 mL, 0.2 mol) was added dropwise, and the mixture was dropped.Slowly warm to 80 C, stir for 24 h, place the cooled ice bath after cooling.Methanol (50 mL), 3N hydrochloric acid (30 mL) were slowly added dropwise, and the temperature was raised to 80 C.Stir for 4 h, concentrate and dilute with water (100 mL) and wash with diethyl ether (50 mL×2).The aqueous phase is adjusted to pH=10 with saturated sodium carbonate solution.Extracted with EA (50 mL×2), dried and concentrated.17.4 g (85.2%) of a pale yellow oily liquid was obtained.
According to the analysis of related databases, 19472-74-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Liu Zhanzhu; Shen Zhufang; Sun Zhaozhu; Pan Xuan; Zhou Tian; Huan Yi; Guan Baohe; (76 pag.)CN110294744; (2019); A;,
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