Application of 21803-75-8, The chemical industry reduces the impact on the environment during synthesis 21803-75-8, name is 4-Amino-3-chlorobenzonitrile, I believe this compound will play a more active role in future production and life.
Thionylchloride (15 mL) was dropped into water (60 mL) with stirring and cooling sothat the temperature did not rise above -5C. Copper(I) chloride (19 mg) wasthen added. In parallel, 4-amino-3-chlorobenzonitrile (1.50g, 9.83 mmol) wasdissolved in cone. HCl (30 mL), cooled to -5C whereupon a solution of sodiumnitrite (746 mg, 10.8 mmol) in water (15 mL) was added . After completeaddition the solution of diazonium salt was added in over 2 mins to the firstsolution, both at -5 to OoC (gas evolution was observed) and a foam formed ontop of the solution. The temperature was allowed to come to room temperatureand the aqueous phase was then extracted with DCM (3 x 70 ml). The combinedorganic phase was washed with brine (5 mL), dried (Na2SC>4), themixture filtered and the filtrate evaporated to dryness to afford a yellowsolid containing the title compound (1.88 g, 88%); ‘H NMR (500 MHz, CDC13)delta 7.83 (dd, IH), 7.97 (d, IH), 8.31 (d, IH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts