Adding a certain compound to certain chemical reactions, such as: 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-50-1, Quality Control of 2-(3-Nitrophenyl)acetonitrile
(3-Nitro-phenyl)-acetonitrile (1.51 g, 9.31 mmol), dimethoxymethyl-dimethyl-andine (6.2 mL, 46.5 mmol) in xylene (30 mL) are stirred at reflux for 1 hour. After adding hexane (20 mL), the reaction mixture is cooled at 0C. Precipitating material is filtered-off to give compound of Stage 52.1 as brown solid (1.76 g, 8.19 mmol ; 88%); ES-MS: M+H = 218. 1; HPLC: tRet = 2.24 minutes. 1H-NMR (300 MHz, DMSO-d6) : 8.10-8. 05 (m, 1H), 7.90-7. 85 (m, 1H), 7.75-7. 72 (m, 1H), 7.70 (s, 1H), 7.65-7. 60 (m, 1H), 3.30 (s, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Nitrophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/70431; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts