Adding a certain compound to certain chemical reactions, such as: 6575-11-7, name is 2-Amino-6-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6575-11-7, Computed Properties of C7H5ClN2
A mixture of 2-amino-6-chlorobenzonitrile (17.72 g, 0.116 mol) and tetrahydro-2,5- dimethoxyfuran (0.116 mol) in HO Ac (100 ml) was stirred and re fluxed for 30 min. Subsequently, the mixture was cooled and evaporated. The residue was purified over silica gel on a glass filter (eluent: DCM). The product fractions were collected and the solvent was evaporated. The residue was crystallized from EtOH. Yield: 18.83 g of intermediate 3 (80 % yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-6-chlorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; MEERPOEL, Lieven; MAES, Louis, Jules, Roger, Marie; DE WIT, Kelly; AUGUSTYNS, Koen, Jan, Ludovicus; WO2012/150305; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts