Adding a certain compound to certain chemical reactions, such as: 2698-41-1, name is 2-(2-Chlorobenzylidene)malononitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2698-41-1, Safety of 2-(2-Chlorobenzylidene)malononitrile
General procedure: A mixture of 1,3-indandione (0.153 g, 1.05 mmol), 2 (1 mmol), iodine (0.304 g, 1.2 mmol) and DMAP (0.366 g, 3 mmol) was stirred in CH3CN at 40 C. After stirring until conversion was completed, the reaction mixture was partioned between water and ethyl acetate. The aqueous layer was extracted three times with ethyl acetate (3 x 15 mL). The resulting organic layer was washed with 10% NaHSO3 (2 x 15 mL) and then dried over sodium sulfate. After concentration, the crude products 3a – 3n were purified by flash column chromatography
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Chlorobenzylidene)malononitrile, and friends who are interested can also refer to it.
Reference:
Article; Huang, Jiamin; Liu, Wenli; Wang, Changqing; Yang, Liu; Cao, Xiaohua; Tetrahedron Letters; vol. 61; 4; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts