Adding a certain compound to certain chemical reactions, such as: 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13338-63-1, Quality Control of 3,4,5-Trimethoxyphenylacetonitrile
Using the method of synthesizing an intermediate similar to that of Example 1, Take 0.193 g (0.01 mol) of 2-(3,4,5-trimethoxyphenyl)acetonitrile (5), 0.156 g (0.01 mol) of 2-naphthaldehyde, and 20 mL of methanol into a 50 mL three-necked flask. Stirring to 60 C, adding sodium methoxide 0.027 g (0.005 mol), Constant temperature reaction for about 5h, thin layer chromatography to follow the reaction, After the reaction is completed, cool to room temperature, filter, and wash. Dry and recrystallize from methanol to give a pale yellow solid. Yield: 40.6%,
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trimethoxyphenylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Yanbian University; Tian Yushun; Li Jiajun; Ma Jun; (19 pag.)CN109384689; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts