Electric Literature of 154532-34-0,Some common heterocyclic compound, 154532-34-0, name is 3-(tert-Butyl)benzonitrile, molecular formula is C11H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 3-te/t-butylbenzonitrile (400 mg) in MeOH (5 mL), aqueous ammonium hydroxide (ImL) and Raney Nickel (catalytic) were added and the reaction mixture was hydrogenated at 50psi for 2h. Then the reaction mixture was filtered and solvent evaporated. (3-te/t-butylphenyl)methanamine was used without any purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(tert-Butyl)benzonitrile, its application will become more common.
Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts