Application of 7251-09-4, These common heterocyclic compound, 7251-09-4, name is 4-Amino-2-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 148g of 4-cyano-2-methoxyaniline,Add 400g of di-tert-butoxycarbonyl dicarbonate and 5g of ZnOReaction at room temperature for 2h, after the reaction is over,The reaction system is filtered to remove ZnO,The residue was poured into 300 ml of water and extracted with 500 ml of ethyl acetate,The organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was recovered under reduced pressure.246 g of white solid powder was obtained with a yield of 99%.
Statistics shows that 4-Amino-2-methoxybenzonitrile is playing an increasingly important role. we look forward to future research findings about 7251-09-4.
Reference:
Patent; Anhui Cheng Lian Pharmaceutical Technology Co., Ltd.; Liu Hui; Gong Bowen; Feng Chengliang; (11 pag.)CN110981800; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts