Adding a certain compound to certain chemical reactions, such as: 97165-77-0, name is 3,5-Dibromobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97165-77-0, Computed Properties of C7H3Br2N
3-Bromo-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile Tetrabutylammonium fluoride (21 mL, 1M in THF, 21 mmol) was added to a mixture of 3,5-dibromobenzonitrile (5.0 g, 19 mmol), 2-methyl-4-[(trimethylsilyl)ethynyl]-1,3-thiazole (3.8 g, 19 mmol), triethylamine (5.5 mL, 40 mmol), copper (I) iodide (730 mg, 3.8 mmol), dichlorobis(triphenylphosphine)palladium(II) (1.4 g, 1.9 mmol), and N,N-dimethylformamide (25 mL). Nitrogen was bubbled through the resulting mixture for 30 min, and the reaction was heated at 90 C. for 5 h. The reaction was allowed to cool to ambient temperature, poured into a solution of H2O (500 mL) and NH4OH (150 mL), and extracted with methyl tert-butyl ether (100 mL*3). The combined organic extracts were dried (MgSO4), filtered, and concentrated in vacuo. The residue was chromatographed on silica gel with hexanes:EtOAc (9:1?1:1) to afford 3-bromo-5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]benzonitrile as a light-brown solid. 1H NMR (CDCl3, 500 MHz) delta 7.90 (t, J=1.6 Hz, 1H), 7.76-7.73 (m, 2H), 7.46 (s, 1H), 2.75 (s, 3H). MS (ESI) 303.2 (M++H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; US2007/60618; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts