Synthetic Route of 35704-19-9, These common heterocyclic compound, 35704-19-9, name is N-(4-Cyanophenyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
B. 3-nitro-4-acetamidobenzonitrile Sixty-seven grams of potassium nitrate were gradually stirred into 300 ml. of concentrated sulfuric acid at 9 C. to form a paste. Fifty grams of 4-acetamidobenzonitrile were added portionwise to the cold acid mixture. The reaction mixture was maintained at -5 C. for about 1 hour. The thick mixture was poured onto cracked ice. The product was collected and washed with cold water. The wet solid was added portionwise to about 400 ml. of warm acetic anhydride very carefully. Water was added to destroy the excess anhydride. The nitro product was collected and recrystallized from ethanol to yield 25.5 g. of 3-nitro-4-acetamidobenzonitrile m.p. 127-129 C. A second crop, 23 g., was obtained.
Statistics shows that N-(4-Cyanophenyl)acetamide is playing an increasingly important role. we look forward to future research findings about 35704-19-9.
Reference:
Patent; Eli Lilly and Company; US4018790; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts