Adding a certain compound to certain chemical reactions, such as: 2469-99-0, name is 3-Oxobutanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2469-99-0, Safety of 3-Oxobutanenitrile
In a 250 mL RBF, 3-aminobut-2-enenitrile (2.0 g, 0.24 mole) was added to a stirred solution of cyclohexyl hydrazine hydrochloride (4.0 g, 0.026 mole) and acetic acid (0.1 mL) in ethanol (60 mL). The reaction was refluxed for 6 h. Crude was evaporated and loaded on column to elute out product at 40% ethyl acetate in hexane. (1.74 g, 40%) LCMS: RT = 1.50 min., >98% 215 and 254 nm, m/z = 180.1 [M + H]+. 1H NMR (499 MHz, DMSO) delta 5.02 (s, 1H), 4.92 (s, 2H), 3.86 – 3.78 (m, 1H), 1.94 (s, 3H), 1.78 – 1.68 (m, 4H), 1.63 (dd, J = 16.3, 7.4 Hz, 3H), 1.31 (q, J = 12.9 Hz, 2H), 1.18 – 1.08 (m, 1H). 13C NMR (126 MHz, DMSO) delta 145.90, 144.64, 87.80, 53.50, 32.13, 25.21, 25.05, 14.02.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Oxobutanenitrile, and friends who are interested can also refer to it.
Reference:
Article; Sharma, Swagat; Kozek, Krystian A.; Abney, Kristopher K.; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; David Weaver; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 6; (2019); p. 791 – 796;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts