In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76469-88-0, name is Methyl 4-(cyanomethyl)benzoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 4-(cyanomethyl)benzoate
Step 2: Synthesis of (Z)-methyl 4-(2-(6-chloro-1-(4-fluorobenzyl)-1H-indazol-3-yl)-1-cyanovinyl)benzoateThe product from step 1 (30.8mg, 0.106mmol), methyl 4-(cyanomethyl)benzoate (18.7mg, 0.106mmol), NaOH (4.3mg, 0.106mmol) were dissolved in MeOH (l . lmL) at room temperature then heated to 50C for 20 minutes. The mixture was then cooled, filtered and dried to give a solid (49mg).
The synthetic route of 76469-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAKEA, INC.; HUTCHINSON, John, Howard; PARR, Timothy, Andrew; BUNKER, Kevin, Duane; LONERGAN, David; WO2015/42052; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts