Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Methyl-3-nitrobenzonitrile
General procedure: To a screw-capped vial (50 ml) were added iodobenzene 1a(1.0 mmol), substituted benzonitrile 2 (2.0 mmol), K2CO3 (276 mg,2.0 mmol), NaOH (40 mg,1.0 mmol), CuI (19 mg, 0.1 mmol), DMEDA(9 mg, 0.1 mmol), and [bmim]PF6 (14 mg, 0.05 mmol) in water(2 ml). The vial was flushed with nitrogen then sealed with the cap,and allowed to stir at 100 C for the specific reaction time. Thereaction mixture was extracted with EtOAc (315 ml). The combinedorganic extracts were dried over Na2SO4 for 12 h and evaporatedunder vacuum. The crude products were purified in a silicagel column for further purification, using PE/EtOAc (5:1) as theeluent.
According to the analysis of related databases, 939-79-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang; Tetrahedron; vol. 69; 48; (2013); p. 10463 – 10469;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts