Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17626-40-3, name is 3,4-Diaminobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H7N3
3,4-diaminobenzonitrile (42, 2.5g; 18.75mmol; 1.0 equiv) was dissolved in 5M 55 aqueous HCl (110mL). The mixture was heated at 105C to reflux for 12h. After stopping the reaction, the mixture was cooled to room temperature, basified with aqueous ammonia and stored overnight. The generated solid 56 product was collected by filtration and washed with ice water. The products could be used without further purification. Yield: 2.5g (94.0%). 1H NMR (300MHz, DMSO) delta 12.47 (s, 1H), 8.34 (s, 1H), 8.03 (s, 1H), 7.62 (d, J=4.17Hz, 1H), 7.45 (d, J=8.34Hz, 1H). MS m/z: 144.2 [M+ H] +.
The synthetic route of 17626-40-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Li-Li; Wu, Yu-Feng; Wang, Lei; Li, Cui-Cui; Li, Li; Di, Bin; You, Qi-Dong; Jiang, Zheng-Yu; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 1376 – 1394;,
Nitrile – Wikipedia,
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