Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 85068-32-2, name is 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 85068-32-2
Lithium bis(trimethylsilyl)amide (4.9 ml, 1 .0 M in THF, 4.9 mmol) was added dropwise to a solution of [3,5-bis(trifluoromethyl)phenyl]acetonitrile (1 .00 g, 3.95 mmol) and 1 ,4- dibromobutane (700 mI, 5.9 mmol) in THF (25 ml) at OO and the mixture was stirred for 2 h at room temperature. Lithium bis(trimethylsilyl)amide (4.9 ml, 1.0 M in THF, 4.9 mmol) was added and the mixture was stirred over night at room temperature followed by 3 h at 600. For the work-up, the mixture was poured into brine, extracted with ethyl acetate (3x) and the combined organic phases were dried and concentrated. The residue was purified by flash chromatography (hexanes/ethyl acetate 95:5) to give the title compound 866 mg (68 % yield). 1 H-NMR (400 MHz, DMSO-afe): d [ppm] = 8.18 (s, 2H), 8.16 (s, 1 H), 2.60-2.52 (m, 2H), 2.23- 2.13 (m, 2H), 1 .98-1.86 (m, 4H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 85068-32-2.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; WITTROCK, Sven; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; (388 pag.)WO2020/48830; (2020); A1;,
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