Reference of 1897-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1897-52-5, name is 2,6-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1 2-Amino-6-fluoro-benzonitrile 50 parts of 2,6-difluorobenzonitrile and 40 parts by volume of ammonia are stirred for 10 hours at 100 C. in a closed vessel. The reaction mixture is taken up in methylene chloride, the solid is filtered off, the organic phase is extracted three times by shaking with water and is dried over sodium sulfate, the solvent is stripped off and the residue is dried under reduced pressure. 48 parts (98.1% of theory) of 2-amino-6-fluoro-benzonitrile, of solidification point 125-128 C., are obtained.
The synthetic route of 2,6-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF Aktiengesellschaft; US4359428; (1982); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts