Synthetic Route of 4421-09-4, A common heterocyclic compound, 4421-09-4, name is 3,4-(Methylenedioxy)benzonitrile, molecular formula is C8H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of nitrile (1 mmol), sodium azide (1.5 mmol), catalyst (40 mol%) and DMF (3 mL) was taken in a round-bottomed flask and stirred at 120 C temperature for 12 h. After completion of the reaction the catalyst was separated from the reaction mixture with an external magnet and reaction mixture was treated with ethyl acetate (30 mL) and 5 N HCl (20 mL). The resultant organic layer was separated and the aqueous layer was again extracted with ethyl acetate (20 mL). The combined organic layers were washed with water, concentrated, and the crude material was chromatographed on silica gel (Hexane-EtoAc, 1:1) to afford the pure product. refText
The synthetic route of 4421-09-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sreedhar; Kumar, A. Suresh; Yada, Divya; Tetrahedron Letters; vol. 52; 28; (2011); p. 3565 – 3569;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts