Adding a certain compound to certain chemical reactions, such as: 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50594-78-0, COA of Formula: C7H3FN2O2
To a solution of 5-fluoro-2-nitrobenzonitrile (1 g, 6 mmol) and 3,5- difluorobenzenethiol (1.03 g, 7.05 mmol) in DIVIF (20 mL), was added K2C03 (2.5 g, 18 mmol). The reaction was stirred at 80 C for 1.5 hrs. The residue was poured into H20 (20 mL) and the aqueous phase was extracted with EA (30 mL x2). The organic layer was washed with brine (25 mL), dried over Na2SO4 and concentrated. The residue was purified by silica gel column (PE/EA = 3/1) to give 5-((3,5-difluorophenyl)thio)-2-nitrobenzonitrile (1.4 g, yield: 90%) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoro-2-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts