3215-64-3, name is 2-(2,6-Dichlorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(2,6-Dichlorophenyl)acetonitrile
To a solution of 2, 6-dichloro-phenyl-acetonitrile (15. 0g, 80.62 mmol) in the dichloromethane (50 mL) and H2S04 (40 mL) is added (slowly) a mixture of H2SO4 (14 mL) and HN03 (5.5 mL) at 0C. The reaction mixture is stirred at 0C for 20 minutes, warmed to room temperature for half hour, and then concentrated to remove organic solvent. The solution is poured into a beaker containing ice-water (400 mL) to give a crystalline precipitate, which is collected by vacuum filtration and washed with water to afford the product (20.44 g, 82.4%).
The synthetic route of 3215-64-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; WO2005/34869; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts