Reference of 115279-57-7, The chemical industry reduces the impact on the environment during synthesis 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, I believe this compound will play a more active role in future production and life.
18 g (62.6 mmol) of 6-bromo-4-chloro-3-nitro-quinoline (Example lc) and 11 g(68.9 mmol) of (2-(4-amino-phenyl)-2-methyl-propionitrile (Example le) are dissolved in 350 ml of acetic acid and stirred for 2 h. After this time, water is added and the yellow precipitate is filtered off and washed with H2O. The solid is dissolved in EtOAc-THF (1 : 1), washed with sat. aqueous NaHC03and dried over MgS04. The organic phase is evaporated to dryness to give the title compound as a yellow solid. ES-MS: 411, 413 (M + H)+, Br pattern; analytical HPLC: tret= 3.69 min (Grad 1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Aminophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo; WO2013/23119; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts