Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 42872-74-2, name is 3-Bromo-4-methylbenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C8H6BrN
Dissolve 3-bromo-4-methylbenzonitrile (10g, 51mmol) in carbon tetrachloride (100mL), add NBS (22.6g, 127.5mmol) and benzoyl peroxide (272mg, 2.5mmol), and reflux 14h, the raw materials disappeared. Cool to room temperature, add water (400 mL), extract with DCM (200 mL × 2), and obtain column chromatography (P / E = 20: 1) to obtain 16.17 g of white solid with a yield of 89.6% and melting point: 48-49 C.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Cui Guonan; Lai Fangfang; Zhou Jie; Ji Ming; Wang Xiaoyu; Du Tingting; Li Ling; Jin Jing; (144 pag.)CN110483366; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts