In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-51-8 as follows. Recommanded Product: 57381-51-8
Example 19: Scheme G2; Potassium tert-butoxide (2.1 equiv., 13.5 mmol, 1.51 g) was added to a stirred solution of 4-chloro-2-fluorobenzonitrile (G2.1) (1 equiv., 6.43 mmol, 1.0 g) and 3-amino-6- chloropyridine (1 equiv., 6.43 mmol, 0.826 g) in DMSO (3 ml). The reaction mixture was stirred at room temperature for 0.5 h. Water was added, the resulting precipitate was filtered off and washed successively with water, isopropanol and isopropyl ether to give G2.2 (1.17 g, yield = 69%).
According to the analysis of related databases, 57381-51-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2008/37784; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts