Reference of 94088-46-7, A common heterocyclic compound, 94088-46-7, name is 2-Fluoro-6-methoxybenzonitrile, molecular formula is C8H6FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : A solution of 2-fluoro-6-methoxybenzonitrile (10 g, 66.2 mmol) in (0490) trifluoromethanesulfonic acid (100 mL) at 0C was treated with N-bromosuccinimide (12.4 g, 69.5 mmol) and the mixture was allowed to warm to RT and was stirred for 3 days. The reaction mixture was cooled to 0 C, quenched with ice, and made basic with 6 M KOH, and the resulting solid was collected by filtration. The filter cake was dissolved in ethyl acetate and dried over sodium sulfate, and the mixture was filtered. The filtrate was concentrated to afford an approximately 1 :1 mixture of 3-bromo-6-fluoro-2-methoxybenzonitrile and 3-bromo-2-fluoro- 6-methoxybenzonitrile, which was used in the next step without purification or analysis.
The synthetic route of 94088-46-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BURSULAYA, Badry; FISCH, Andreas; LAJINESS, James Paul; MACHAUER, Rainer; MALEKAR, Swapnil; PETRASSI, Hank Michael James; RAMAZANI, Farshad; REMOND, Anne-Catherine; ULLRICH, Thomas; USSELMANN, Peggy; VANGREVELINGHE, Eric; (145 pag.)WO2018/55550; (2018); A1;,
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