The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.
Related Products of 56043-01-7, A common heterocyclic compound, 56043-01-7, name is 2-Amino-6-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
PREPARATION 9; Preparation of 1 ,8-bis(bromomethyl)-9/-/-fluoren-9-one; A. Preparation of 2-(imino(o-tolyl)methyl)-3-methylaniline; To a cooled (0 0C) solution of 2-amino-6-methylbenzonitrile (5.00 g, 37.81 mmol) in anhydrous tetrahydrofuran (50 mL) was added dropwise a solution of 2- methylphenylmagnesium bromide (77.5 ml_ of a 2 M solution in diethyl ether, 155.0 mmol). The resultant mixture was then heated at reflux for 16 h and allowed to cool to ambient temperature. The reaction mixture was then poured into ice-water (500 mL) and concentrated hydrochloric acid (100 mL) was added. The mixture was transferred to a separatory funnel and was washed with diethyl ether (3 chi 100 mL). The aqueous phase was rendered alkaline by the addition of solid sodium hydroxide (8.0 g) and was extracted with dichloromethane (3 x 150 mL). The combined dichloromethane extract was washed with brine (150 mL), dried over sodium sulfate and filtered. The filtrate was concentrated in vacuo to dryness to afford 2-(imino(o-tolyl)methyl)-3-methylaniline: MS (ES+) m/z 225.3 (M + 1 ).
The synthetic route of 56043-01-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2008/109840; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts