Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H6F3N
General procedure: To a solution of 10 (1.0 mmol, 1.0 equiv.) and substituted benzyl cyanate (1.2 mmol, 1.2 equiv.)in 5 mL of anhydrous DMF was added NaH 60% in mineral oil (66 mg, 2.0 mmol, 2.0 equiv.) at0C. The reaction mixture was allowed to warm to room temperature overnight, and was quenchedwith saturated NH4Cl and extracted with ethyl acetate (3 x 30 mL). The combined organic phaseswere washed with brine, dried over anhydrous MgSO4, filtered and concentrated to yield the crudeproduct. The product was purified via combi-flash on silica gel using 20% EtOAc in hexanes togive the desired product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Tang, Jing; Do, Ha T.; Huber, Andrew D.; Casey, Mary C.; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 390 – 399;,
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