These common heterocyclic compound, 501-00-8, name is 2-(3-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6FN
To a solution of compound 36-2 (346 mg, 2.56 mmol) in THF (10 niL) was added Raney Ni. Then the mixture was adjusted to PH=IO with concentrated aqueous ammonia and stirred at 30 0C overnight. TLC showed the reaction was completed. The mixture was filtered through Celite and the filtrate was concentrated to give 36-3 as a yellow oil (120 mg, yield: 34 %).
The synthetic route of 2-(3-Fluorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY; YUAN, Junying; MA, Dawei; LIU, Junli; ZHANG, Lihong; WO2011/11522; (2011); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts