Reference of 14447-18-8, These common heterocyclic compound, 14447-18-8, name is Benzyl cyanoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 0.2 mmol of 3,4-dihydroxycinnamaldehyde in 3 mL EtOH a corresponding substituted acetonitrile or the like was added followed by addition of 0.4 mmol of piperidine. A dark red solution was stirred at 20 °ree;C for 0.5 h. 0.5 mL 1 N HC1 and 5 mL of H2O were added and EtOH was evaporated with the stream of N2. The precipitated powder was filtered off, washed with H2O and dried in a desiccator in vacuo in the presence of solid NaOH. Yields were 55-70%. For a list of obtained products (CRIX-38, CRIX-39, CRIV-42, CRIV-46, CRTX-79, CRVIII-33, CRVIII-34, CRVIII-50, CRVIII-51, CRVIII-52, CRVIII-53) see Tables 1 and 5. For the mass spectra and UV maxima see Tables 2 and 6. For the NMR data see Tables 3 and 7.
Statistics shows that Benzyl cyanoacetate is playing an increasingly important role. we look forward to future research findings about 14447-18-8.
Reference:
Patent; THE HOSPITAL FOR SICK CHILDREN; WO2005/12234; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts