Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89001-53-6, name is 2-Methyl-4-nitrobenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 89001-53-6
3-Methyl-4-oxazol-5-yl-phenylamine was prepared in two steps from 2-methyl-4- nitrobenzaldehyde in analogy to intermediate 1. 2-Methyl-4-nitrobenzaldehyde was preparedaccording to the following procedure:2-methyl-4-nitrobenzonitrile (1 g, 6.1?7 mmol) was dissolyed in dry toluene (24.0 ml). After cooling to 0C, a solution of DIBAL-H (4.35 ml, ?7.4 mmol) in toluene was added drop wise oyer 10 min. The mixture was stirred for 2h at 0C. The mixture was quenched at 0C by addition of HC1 2N (1 ml). After warming to room temperature and addition of further HC1 2N (1 ml),sodium sulfate was added under yigorous stirring. Filtration of the solids and eyaporation yielded a crude, which was purified by flash chromatography (heptane/AcOEt), to yield 2- methyl-4-nitrobenzaldehyde as an orange solid (0.68 g, 67%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CECCARELLI, Simona M.; JAGASIA, Ravi; JAKOB-ROETNE, Roland; PETERS, Jens-Uwe; WICHMANN, Juergen; WO2014/79850; (2014); A1;,
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