Related Products of 17823-40-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17823-40-4 as follows.
A mixture of 2-ethynyl-1,3-dimethylbenzene (Compound 6) (0.4 g, 3.0 mmol), 4-bromo-2,3,5,6-tetrafluorobenzonitrile (0.38 g, 1.5 mmol), Pd(PPh3)4 (0.173 g,0.15 mmol), Cul (0.057 g, 0.3 mmol) and diisopropylamine (0.4 g, 4 mmol) in dioxane (40 mL) was degassed and heated at about 80 C for about 16 hours. The resulting mixture was worked up with ethyl acetate. After filtered off precipitate, the solution was loaded on silica gel and purified by flash column using eluents of hexane to hexane/dichloromethane (4:1). Removal of solvent give a white solid (Compound 7) (0.4 g, in 88% yield).
According to the analysis of related databases, 17823-40-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NITTO DENKO CORPORATION; ZHENG, SHIJUN; BASIAGO, ADAM; (86 pag.)JP2016/526025; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts