Adding a certain compound to certain chemical reactions, such as: 1483-54-1, name is 2-Amino-4-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1483-54-1, Product Details of 1483-54-1
Potassium iodide (5.6 g, 34 mmol) and sodium nitrite (2.4 g, 35 mmol) were added to a solution of 2-amino-4-trifluoromethyl-benzonithle (2.58 g, 14 mmol) in acetonithle (60 ml_). The resultant mixture was cooled to 0 C in an ice-water bath with magnetic stirring. Ice-cold concentrated HCI (14 ml_) was added slowly drop-wise to the reaction mixture, causing the reaction mixture to become cloudy and deep red in color. The reaction mixture was stirred at 0 C for 30 minutes, then warmed to room temperature. Stirring at room temperature proceeded for 3 hours. The reaction mixture was poured into water, and the resulting suspension was extracted with ethyl acetate. The organic layer was dried (Na2SO4), filtered, and concentrated to give a purple liquid. A solution of this crude product and dichloromethane (200 ml_) was evaporated onto silica gel, and the dry silica gel-supported product was loaded onto a silica gel column. Manual flash chromatography using 5% ethyl acetate in hexanes afforded 2-iodo-4-trifluoromethyl-benzonithle as 3.58 g (87%) of a purple, crystalline solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FIROOZNIA, Fariborz; GILLESPIE, Paul; LIN, Tai-An; MERTZ, Eric; SIDDURI, Achyutharao; SO, Sung-Sau; TAN, Jenny; THAKKAR, Kshitij Chhabilbhai; WO2010/55005; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts