Electric Literature of 403-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A mixture of nitrile (5 mmol), tert-butyl benzoate (5.5 mmol) and Zn(ClO4)2·6H2O (2 mol%) was placed in around bottom flask. Then, the reaction mixture was heated at 50 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), the reaction mixture was quenched with 5-ml water. Then the reaction system was added 10 ml aqueous NaOH solution (1 mol/L) and continued to be stirred 5 min and extracted with ethyl acetate (3 × 10 ml). The organic layers were collected, combined, washed with water (3 × 10 ml), driedover anhydrous Na2SO4, and concentrated under vacuum.
The chemical industry reduces the impact on the environment during synthesis 3-Fluorobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Feng, Cheng-Liang; Yan, Bin; Zhang, Min; Chen, Jun-Qing; Ji, Min; Chemical Papers; vol. 73; 2; (2019); p. 535 – 542;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts