In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-84-7, name is 3-Chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Chlorobenzonitrile
General procedure: A 5 mL reaction tube was charged with Phen-MCM-41-CuBr (36 mg, 0.025 mmol), 2-aminopyridine 1 (0.6 mmol), nitrile 2 (0.5 mmol), ZnI2 (16 mg, 0.05 mmol), and 1,2-dichlorobenzene (1.5 mL) under an air atmosphere. The reaction tube was sealed and placed in an oil bath at r.t. The reaction mixture was stirred at 130 C for 24 h. After cooling to r.t., the reaction mixture was diluted with EtOAc (10 mL) and filtered. The supported copper catalyst was washed with water (2 5 mL) and acetone (2 5 mL), and reused in the next run. The filtrate was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel (hexane/EtOAc, 3:2) to provide the desired product 3.
The synthetic route of 766-84-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xia, Jianhui; Huang, Xue; Cai, Mingzhong; Synthesis; vol. 51; 9; (2019); p. 2014 – 2022;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts