Reference of 302912-31-8, These common heterocyclic compound, 302912-31-8, name is Ethyl 2-(4-cyanophenyl)-2-oxoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of (4-cyano-phenyl)-oxo-acetic acid ethyl ester 1.0 g, 4.9 mmol) in 20 mL of dichloromethane and (diethylamino)sulfur trifluoride (DAST) (1.0 g, 6.2 mmol) was stirred at r.t. for 3 hrs. The mixture was poured into iced water and extracted with ethyl acetate. The organics were dried over MgSO4 and concentrated to give crude (4-cyano-phenyl)-difluoro-acetic acid ethyl ester which was used for the reaction.
Statistics shows that Ethyl 2-(4-cyanophenyl)-2-oxoacetate is playing an increasingly important role. we look forward to future research findings about 302912-31-8.
Reference:
Patent; Wyeth; US2005/131014; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts