The important role of 4-(2-Hydroxyethyl)benzonitrile

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Adding a certain compound to certain chemical reactions, such as: 69395-13-7, name is 4-(2-Hydroxyethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69395-13-7, Recommanded Product: 4-(2-Hydroxyethyl)benzonitrile

Compound 22:Ferrocene (11.0 mg, 0.050 mmol) was added sequentially to a 25 mL two-necked flask,4-cyanobenzene ethanol (43.2 mg, 0.25 mmol),Phenyl silane (109 [mu] L, 0.75 mmol)Tert-butyl hydroperoxide (88 [mu] L, 0.75 mmol)The gas was replaced with dry N2 for 3 times,Finally, dry tetrahydropyran (2.0 mL) was added under N2.The mixture was stirred at room temperature and heated to 80 C to carry out the reaction,Until the thin layer chromatography monitoring of raw materials is completed.At the end of the reaction, 15.0 mL of NaCl solution was added at room temperature,Extracted with ether 15.0mL three times, combined with organic phase decompression steaming,The product was purified by column chromatography in 65% yield.

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Reference:
Patent; Nanjing Normal University; Han Wei; Zhao Hongyuan; (19 pag.)CN107056732; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts