Some common heterocyclic compound, 621-03-4, name is 2-Cyano-N-phenylacetamide, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Cyano-N-phenylacetamide
General procedure: 10 mmol of 2-cyano-N-phenylacetamides (4, 5), 10 mmol of aromatic aldehyde (6a-h) and malononitrile (7) were dissolved in 20 ml of methanol. The reaction mixture was heated on water bath for 8-16 h using piperidine as catalyst 24 (under TLC analysis). After completion of the reaction, the reaction mixture was cooled to room temperature; separated product was filtered, washed with methanol and crystallized from DMF to afford the desired products 8, 9. The compound 9d is reported in literature.25
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 621-03-4, its application will become more common.
Reference:
Article; Khatri, Taslimahemad T.; Shah, Viresh H.; Journal of the Korean Chemical Society; vol. 58; 4; (2014); p. 366 – 376;,
Nitrile – Wikipedia,
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