Synthetic Route of 23842-82-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23842-82-2, name is 2-Amino-5-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[0340] Following a reported procedure (Michaelidou, S. S.; Koutentis, P. A. Tetrahedron 2010, 66, 685-688), 2-amino-5-methoxybenzonitrile (Manetsch, R. et al. Chem. Eur. J. 2004, 10, 2487-2506) (0.109 g, 0.74 mmol) was treated with paraformaldehyde (0.024 mg, 0.81 mmol), potassium cyanide (0.053 g, 0.81 mmol), zinc chloride (0.201 g, 1.473 mmol) and sulfuric acid (1 drop) in acetic acid (2.2 mL) in a sealed tube. The mixture was then stirred at 55 C. overnight. The reaction mixture was allowed to cool to room temperature, poured onto ice and made pH neutral with Na2CO3. Filtration of the precipitate gave the title compound (0.068 g, 50%). [0341] 1H NMR (CDCl3, 400 MHz) delta 7.11 (dd, 1H, J=2.8, 9.1 Hz), 6.98 (d, 1H, J=2.8 Hz), 6.75 (d, 1H, J=9.1 Hz), 4.15 (s, 2H), 3.74 (s, 3H). [0342] MS (ESI) m/z 188.1 [M+H]+ ([M+H]+, C10H10N3O requires 188.2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Board of Regents of The University of Texas System; McKnight, Steven L.; Pieper, Andrew A.; Ready, Joseph M.; Fernandez, Enrique; US2014/57900; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts