Adding a certain compound to certain chemical reactions, such as: 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19924-43-7, Safety of 2-(3-Methoxyphenyl)acetonitrile
A mixture of (3-methoxyphenyl)acetonitrile (13.0 g, 88.0 mmol), O,O-diethyl dithiophosphate (14.9 mL, 97.0 mmol) and 4M hydrogen chloride-1,4-dioxane (177 mL, 707 mmol) was stirred at room temperature for 18 hr. The reaction mixture was diluted with ethyl acetate (200 mL), water (200 mL) was added, and the organic layer was separated, washed successively with water (100 mL), 0.2N aqueous sodium hydroxide solution (100 mL) and saturated brine (100 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained residue was treated with hexane (200 mL) in an ice bath to allow solidification. The solid was collected by filtration, and washed with hexane to give the title compound (12.6 g) as a white solid (yield 79%). 1H NMR (400 MHz, CDCl3) 5 3.81 (3H, s), 4.10 (2H, s), 6.49 (1H, brs), 6.80-6.81 (1H, m), 6.84-6.89 (2H, m), 7.31 (1H, t, J = 8.0 Hz), 7.46 (1H, brs).
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Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2530078; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts