Adding a certain compound to certain chemical reactions, such as: 1187-42-4, name is Diaminomaleonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1187-42-4, SDS of cas: 1187-42-4
,2-bis(4-chlorophenyl)ethane-l,2-dione, (20 g, 71.65 mmol), diaminomaleonitrile (8.5 g,78.82 mmol) and acetic acid (6 ml) in ethanol (140 ml) and water (93 ml) were heated at75 °C overnight. The reaction mixture was cooled, and water was added. The precipitatewas filtered and washed with ethanol and then ether. The crude product was dissolved inDCM and treated with activated charcoal, then filtered through celite. After evaporation, asolid was formed and recrystallized from DCM/ethanol to give a pale yellow solid (17.3 g,69percent).JH NMR (400 MHz) 8 7.49 (d, 4H), 7.38 (d, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diaminomaleonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; WO2004/111039; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts