Reference of 251570-03-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 251570-03-3 name is 2-(4-Chloro-3-fluorophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of the product of example 22 (7.8g, 0.046 mol), water (7.5 ml), concentrated sulfuric acid (7.5ml) and acetic acid (7.5ml) was heated at reflux for 2 hours . After being cooled to room temperature, the mixture was poured into ice-water. The resulting solids were collected by filtration and washed by diethyl ether to give the titled product (6.8g, 79%)1H NMR (300 MHz, DMSO-/) 3.64 (s, 2H), 7.14 (ddd, J= 0.6, 2.1, 8.2 Hz, IH), 7.34 (dd, J= 2.1, 10.6 Hz, IH), 7.52 (t, J=8.1 Hz, IH).MS (ESI”) m/z 187 (M-I)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Chloro-3-fluorophenyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; AVEXA LIMITED; DEADMAN, John, Joseph; JONES, Eric, Dale; LE, Giang, Thanh; RHODES, David, Ian; THIENTHONG, Neeranat; VAN DE GRAFF, Nicholas, Andrew; WINFIELD, Lisa, Jane; WO2010/31; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts