In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872091-83-3, name is Methyl 4-chloro-3-(cyanomethyl)benzoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 872091-83-3
Step 3: Intermediate 3 [00778j To a solution of Intermediate 2 (920 mg, 4.41 mmol) in MeOH (10 mL) was added H2S04 (4 mL) at 25 C. The mixture was allowed to stir at 60 C for 16 h. The mixture was basified with saturated aqueous Na2CO3 to pH 8 and extracted with DCM. The combined organic layers were dried over anhydrous Na2SO4 and concentrated to afford the title compound as off- white solid (910 mg, 86%). ?H NMR (400 MHz, CDC13): oe 7.97 (d, 1H), 7.46 (d, 1H), 7.90 (dd, 1H), 3.91 (s, 3H), 3.83 (s, 2H), 3.72 (s, 3H).
The synthetic route of 872091-83-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; SANOFI; D’AGOSTINO, Laura Akullian; SJIN, Robert Tjin Tham; NIU, Deqiang; MCDONALD, Joseph John; ZHU, Zhendong; LIU, Haibo; MAZDIYASNI, Hormoz; PETTER, Russell C.; SINGH, Juswinder; BARRAGUE, Matthieu; GROSS, Alexandre; MUNSON, Mark; HARVEY, Darren; SCHOLTE, Andrew; MANIAR, Sachin; WO2014/144737; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts