Electric Literature of 447-60-9, These common heterocyclic compound, 447-60-9, name is 2-(Trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The mixture of 1-ferrocenyl-2-methylpropan-1-ol (1) (645 mg, 2.5 mmol) and the nitrile 2 (2.5 or 3.0 mmol) in DCE(5 mL) was added dropwise with vigorous stirring to MsOH (1.30 mL, 20 mmol) at room temperature. The resulting mixture was then heated with stirring at 60 C for the noted reaction time. After, the reaction mixture was cooled to roomtemperature, poured into a mixture of crushed ice (20 g) and 25% aq NH3 (6 mL) and extracted with EtOAc (80 mL × 3). The combined organic layers were washed with water, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. Purification of the crude mixture by silica gel column chromatography gave the desired product 3
Statistics shows that 2-(Trifluoromethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 447-60-9.
Reference:
Article; Rozhkova, Yuliya S.; Plekhanova, Irina V.; Gorbunov, Alexey A.; Stryapunina, Olga G.; Chulakov, Evgeny N.; Krasnov, Victor P.; Ezhikova, Marina A.; Kodess, Mikhail I.; Slepukhin, Pavel A.; Shklyaev, Yurii V.; Tetrahedron Letters; vol. 60; 11; (2019); p. 768 – 772;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts