Reference of 6283-71-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6283-71-2, name is Dimethyl 2-cyanosuccinate, This compound has unique chemical properties. The synthetic route is as follows.
Cyanodiester 12 (1.16 g; 6.78 mmol) was dissolved in ethanol/water 1:1 (12 mL), cooled to 0-5 C and Et3N (1.2 mL) was added dropwise. After 15 min tert-butyl acrylate (1.05 mL; 0.92 g; 7.14 mmol) was added dropwise. The mixture was stirred at 0-5 C for 1.5 h, allowed to warm to room temperature and stirred for further 2 h. It was then concentrated, diluted with water, acidified with 2 N HCl to pH 4 and extracted 3* with AcOEt. The combined organic extracts were dried with MgSO4, concentrated in vacuo and chromatographed on silica gel in hexane/AcOEt (4:1) to give 20 (0.61 g; 29%; Rf 0.27) and 21 (0.77 g; 38%; Rf 0.23) as colourless oils.
The chemical industry reduces the impact on the environment during synthesis Dimethyl 2-cyanosuccinate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Weinberg, Kamil; Stoit, Axel; Kruse, Chris G.; Haddow, Mairi F.; Gallagher, Timothy; Tetrahedron; vol. 69; 23; (2013); p. 4694 – 4707;,
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