Adding a certain compound to certain chemical reactions, such as: 138642-47-4, name is 2-Bromo-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 138642-47-4, Computed Properties of C8H6BrNO
B. Synthesis of 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile A mixture of 2-bromo-5-methoxybenzonitrile (82.6 g, 0.39 mol, 1 equiv), bis(pinacolato)diboron (109.1 g, 0.43 mol, 1.1 equiv) and potassium acetate (115.3 g, 1.17 mol, 3 equiv) in a mixture of 1,4-dioxane (400 mL) and DMSO (40 mL) was sparged with nitrogen for 1 hour. Pd(dppf)Cl2 (7.13 g, 5 mol %) was added and reaction mixture was gently heated at 60 C. for 2 hours then refluxed for 16 hours. The mixture was filtered through celite and the solids isolated from the filtrates were washed with isopropanol and heptanes to give the desired product as an off-white solid (57.41 g, 57% yield). Additional product (?10 g) was isolated from the filtrates.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; BROOKS, Jason; SZIGETHY, Geza; MORELLO, Glenn; DENG, Jun; DJUROVICH, Peter I.; CHEN, Hsiao-Fan; (206 pag.)US2016/72082; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts