Reference of 74231-65-5, The chemical industry reduces the impact on the environment during synthesis 74231-65-5, name is 4-(Dichloromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.
Under argon protection,Add 400 mL dioxane to a 2 L round bottomed flaskwithCyano dichlorobenzene 55g,The mixture was cooled to -30 C,Then slowly added dropwise 200mL,1mol / L dimethyl zinc n-hexane solution.Bi completed,The reaction was stirred at this temperature for 2 hours,A large number of reaction bottle appeared brown precipitate,For p-cyanodimethylzinc complex.Weigh 146g of triphenylphosphine ruthenium dichloride,With 180mL dissolved in dioxane was added to the reaction,The reaction was stirred at -20 C for 2 hours.Weigh tricyclohexyl phosphine 136g,Dissolved in 160mL dioxane was added to the reaction flask,The reaction was stirred for 1 hour,A purple solution.Most of the solvent and the volatile matter were distilled off under reduced pressure,The residue was recrystallized from 800 mL of methanol for 1 hour at room temperature,Get a lot of brown red product,filter,The solid was washed several times with methanol,Vacuum drying provided catalyst precursor 1 (89 g,Yield 71%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Dichloromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhongyou Haike Ranqi Co., Ltd.; Shanghai Chemical Institute Co., Ltd.; Luo Yong; Ping Jian; Wang Yuan; Shen Kaimin; Yang Weicheng; Chen Fuxiang; Fang Chao; (9 pag.)CN107216355; (2017); A;,
Nitrile – Wikipedia,
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