Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4387-32-0, name is 2-Chloro-5-methylbenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-5-methylbenzonitrile
To a solution of 2-chloro-5-methyl-benzonitrile (9.0 g, 59.4 mmol) in anhydrous THF (90 mL) at 0 C was added BH3-THF (1.0 M, 178 mL, 178 mmol) dropwise under a nitrogenatmosphere. The mixture was stirred at room temperature for 12 h. The reaction was quenched with 2N HC1 (110 mL) at 0 C and then heated to 70 C for 1 h. After cooling the reaction to room temperature, the solution was washed with DCM (150 mL). The aqueous phase was basified with iN NaOH to pH 8 and then extracted with DCM (150 mL x 3). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give thetitle compound (5.8 g, 63%) as yellow oil. ?HNMR (400 IVIFIz, CDC13) 7.22 (d, J 8.0 Hz,1H), 7.17 (s, 1H), 6.99 (d, J= 8.0 Hz, 1H), 3.88 (s, 2H), 2.32 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy M.; WAI, John; LAI, Kwong Wah; WANG, Fei; CHEN, Kevin X.; (351 pag.)WO2017/205538; (2017); A1;,
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