Related Products of 13726-21-1, These common heterocyclic compound, 13726-21-1, name is 2-(4-Chloro-3-methoxyphenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The third process; (4-Chloro-3-methoxyphenyl) acetic acid methyl ester; Potassium hydroxide (5.86 g) was dissolved in water (25 ml) and the mixture was added to a solution of 4-chloro-3-methoxyphenylacetonitrile (3.80 g) in ethanol (80 ml) at room temperature. The reaction solution was refluxed for 1.5 hours. After cooling, concentrated hydrochloric acid (8.8 ml) and water (50 ml) were added to the reaction solution and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over magnesium sulphate. The solvent was evaporated under reduced pressure. The obtained residue was dissolved in methanol (100 ml) and concentrated sulphuric acid was added thereto. The mixture was refluxed for 1.45 hours. After cooling, the reaction solvent was evaporated under reduced pressure and water was added thereto. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over magnesium sulphate. The solvent was evaporated under reduced pressure to give a title compound (4.43 g). The yield was 99 %. 1H-NMR (CDCl3) delta: 3.61(2H,s), 3.71(3H,s), 3.91(3H,s), 6.81(1H,dd,J=1.8,8.1Hz), 6.87(1H,d,J=1.8Hz), 7.30(1H,d,J=8.1Hz).
The synthetic route of 13726-21-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shionogi Co., Ltd.; EP1887000; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts